Last edited by Aragis
Tuesday, April 28, 2020 | History

4 edition of Oxidative Stress, Lipoproteins and Cardiovascular Dysfunction (Portland Press Research Monograph, 7) found in the catalog.

Oxidative Stress, Lipoproteins and Cardiovascular Dysfunction (Portland Press Research Monograph, 7)

  • 224 Want to read
  • 6 Currently reading

Published by Ashgate Publishing .
Written in English

    Subjects:
  • Biochemistry,
  • Cardiovascular medicine,
  • Metabolism,
  • Cardiology,
  • Arteriosclerosis,
  • Medical,
  • Medical / Nursing

  • Edition Notes

    ContributionsC. Rice-Evans (Editor), K. R. Bruckdorfer (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages184
    ID Numbers
    Open LibraryOL12001475M
    ISBN 101855780453
    ISBN 109781855780453

    The ASK1-signalosome→p38 MAPK and SAPK/JNK signaling networks promote senescence (in vitro) and aging (in vivo, animal models and human cohorts) in response to oxidative stress and inflammation. These networks contribute to the promotion of age-associated cardiovascular diseases of oxidative stress and inflammation. Furthermore, their inhibition delays the onset of these cardiovascular Cited by: 1. Several factors like infection, hyperglycaemia, hyperlipidaemia, malignancy, oxidative stress, and aging can interfere in endothelial function. It is believed that most of the cardiovascular diseases originate from endothelial : Indranil Biswas, Gausal A. Khan.   Markers of oxidative stress are elevated in CHF patients and have been correlated with myocardial dysfunction and overall severity of heart failure. An obvious mechanism through which myocardial oxidative stress might impair cardiac function is through oxidative damage to cellular proteins and membranes, thereby, inducing cellular dysfunction Cited by: Cardiovascular diseases (CVDs) are devastating disorders and the leading cause of mortality worldwide. The pathophysiology of cardiovascular diseases is complex and multifactorial and, in the past years, mitochondrial dysfunction and excessive production of reactive oxygen species (ROS) have gained growing attention. Indeed, CVDs can be considered as a systemic alteration, and understanding.


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Oxidative Stress, Lipoproteins and Cardiovascular Dysfunction (Portland Press Research Monograph, 7) Download PDF EPUB FB2

Oxidative stress, lipoproteins and cardiovascular dysfunction. London: Portland, © (OCoLC) Online version: Oxidative stress, lipoproteins and cardiovascular dysfunction. London: Portland, © (OCoLC) Document Type: Book: All Authors / Contributors: Catherine Rice-Evans; K R Bruckdorfer.

The authors showed that this new diet attenuated levels of oxidative stress biomarkers, reduced android fat mass, and decreased blood pressure in obese patients [ 18 ]. Along the same lines, Tie et al. demonstrated that polypeptides isolated from achyranthes bidentata, a commonly used Chinese medicinal herb, Cited by: Oxidative Stress Oxidative Stress Lipid Peroxidation – A Lipid Metabolism Dysfunction.

By Claudia Borza, Danina Muntean, Cristina Dehelean, Germaine Săvoiu, Corina Şerban, Georgeta Simu, Mihaiela Andoni, Marius Butur and Simona Drăgan. Submitted: November 3rd Reviewed: July 16th Published: January 23rd DOI: /Cited by: 7.

Oxidative stress may represent a common mechanism by which different cardiovascular risk factors cause endothelial dysfunction and trigger atherothrombotic process.

R EVIEW A RTICLE High Blood. Oxidative Stress in Cardiovascular Disease Gábor Csányi 1, * and Francis J. Miller Jr. 2, * 1 Vascular Medicine Institute, EB BST, University of Pittsburgh, Lothrop Street.

Inflammation and chronic kidney and cardiovascular disease The circulating nature of many inflammatory mediators such as cytokines, and inflammatory or immune cells, indicates that the immune system can act as a mediator of kidney-heart cross-talk and may be involved in the reciprocal dysfunction that is encountered commonly in the cardio-renal Cited by: 7.

The evidence suggests that oxidative stress plays a contributing role in the cardiovascular dysfunction caused by exposure to air pollution. Abstract Cardiovascular causes have been estimated to be responsible for more than two thirds of the considerable mortality attributed to air : Mark R.

Miller. Free radicals, lipoproteins and cardiovascular dysfunction. Author links open overlay panel Catherine Rice-Evans a b K. Richard Bruckdorfer a bCited by: Oxidative Stress and Lipid Peroxidation – A Lipid Metabolism Dysfunction 35 Highly reactive aldehydes are one of the major causative factors in oxidative related cardiovascular pathology and ageing.

Oxidative stress, through the production of reactive oxygen species (ROS), has been proposed as the root cause underlying the development of insulin resistance, β-cell Oxidative Stress, impaired glucose tolerance and type 2 diabetes mellitus (T2DM).Cited by: This review provides an overview of the evidence that oxidative stress is a key pathway for the different cardiovascular actions of air pollution.

Discover the world's research 17+ million members. Oxidative stress is defined as the imbalance between the generation of reactive oxygen species and antioxidant defense mechanisms. The cardiovascular system is a major target for reactive oxygen species.

Cardiomyocytes and the vasculature of the heart can be severely damaged as a result of oxidative stress. In this paper, we discuss recent findings with respect to the role of oxidative stress Cited by:   As oxidative stress is a unifying feature of almost all of the cardiovascular risk factors known to drive the atherosclerotic process, as well as a factor that is increased in response to neurohormonal abnormalities in heart failure and in cardiac ischaemia, a biomarker that reflects oxidative stress may be criticized for its lack of by: Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia.

The endothelium is a major participant in the pathophysiology of diseases, such as. Oxidative stress is far more complex than the plain imbalance between pro- Oxidative Stress antioxidants and involves disrupted signaling due to altered levels, dysfunction or mislocalization of redox intermediates and their enzymatic sources.

Consequently, antioxidant therapy is far more complex than simply antagonizing excess oxidant generation. Need of Antioxidants. It has been reported in epidemiological studies that many of antioxidant compounds posses anti inflammatory, antiatherosclerotic, antitumor, antimutagenic, anticarcinogenic, antibacterial and antiviral activities to greater or lesser extent [59, 64, 70].In many cases, increased oxidative stress is a widely associated in the development and progression of diabetes and its Cited by: Title:Mitochondrial Dysfunction, Oxidative Stress and Diabetic Cardiovascular Disorders VOLUME: 12 ISSUE: 2 Author(s):Garry X.

Shen Affiliation:Diabetes Research Group, University of Manitoba, McDermot Ave, Winnipeg, MB R3E 3P4, Canada. Keywords:Diabetes, reactive oxygen species, mitochondria, NADPH oxidase, diabetic cardiovascular complications.

Chronic HIV infection is a state of oxidative stress driven by several mediators including HIV per se, bacterial translocation, ART, mitochondrial dysfunction, and inflammation.

Oxidative stress contributes to oxidation of : Vasiliki D. Papakonstantinou, Theodoros Kelesidis. Blood cholesterol and LDL levels are well-established risk factors for cardiovascular disease and, in particular, coronary heart disease.

In recent years, the role of LDL in the pathogenesis of atherosclerosis, the underlying cause of coronary heart disease, has been studied by: 7. Based on these considerations, in this chapter, we (1) discussed the role of endothelial dysfunction and its contributing factors, such as oxidative stress and inflammation, in the development of cardiovascular diseases and (2) reported the studies which investigated the effect of tobacco and electronic smoking on the biomarkers of endothelial Author: Roberto Carnevale, Vittoria Cammisotto, Francesca Pagano, Cristina Nocella.

Oxidative Stress in Aging, Hypertension, and Diabetes Mellitus. Oxidative stress is highly relevant to aging and the development of various aging-related cardiovascular diseases, including HF. However, the involvement of specific forms of ROS and each antioxidant and/or ROS-producing enzymes in the process of aging remain by: Diabetic oxidative stress occurs by multiple mechanisms, with prominent roles of mitochondrial dysfunction and NOX enzymes, and in cardiac and vascular dysfunction including chronic inflammation, fibrosis, apoptosis, VSMC proliferation and arterial by:   Hyperglycemia, oxidatively modified atherogenic lipoproteins, and advanced glycation end products are linked to oxidative stress in diabetes.

Mitochondria are one of major sources of reactive oxygen species (ROS) in cells. Mitochondrial dysfunction increases electron leak and the generation of ROS from the mitochondrial respiratory chain (MRC).Cited by: Oxidative stress is a term coined to denote the state of imbalance between the generation of oxidants (ie, free radicals and ions collectively called reactive oxygen species (ROS) and the availability of endogenous antioxidants to scavenge this ROS resulting in an excess production of oxidants [1], [2], [3].Cited by: 9.

Bartekova M, Barancik M, Dhalla NS () Role of oxidative stress in subcellular defects in ischemic heart disease.

In: Gelpi RJ, Boveris A, Paderosa JJ (eds) Biochemistry of oxidative stress: physiopathology and clinical aspects, Advances in biochemistry in health and disease, vol Author: Monika Bartekova, Kristina Ferenczyova, Marek Jelemensky, Naranjan S Dhalla.

Title:Mitochondrial Dysfunction, Oxidative Stress and Diabetic Cardiovascular Disorders VOLUME: 12 ISSUE: 2 Author(s):Garry X. Shen Affiliation:Diabetes Research Group, University of Manitoba, McDermot Ave, Winnipeg, MB R3E 3P4, Canada.

Keywords:Diabetes, reactive oxygen species, mitochondria, NADPH oxidase, diabetic cardiovascular complicationsCited by: Hyperglycemia, oxidatively modified atherogenic lipoproteins, and advanced glycation end products are linked to oxidative stress in diabetes.

Mitochondria are one of major sources of reactive oxygen species (ROS) in cells. Mitochondrial dysfunction increases electron leak and the generation of ROS from the mitochondrial respiratory chain (MRC).Cited by: Increased production of free radicals in the body is known as oxidative stress (1).

Free radicals are continuously formed as a consequence of many oxidative chemical reactions in the body. In addition, the environment is also a source of free radicals; this includes: ionizing radiation, ozone and nitrous oxide, heavy metals (mercury, cadmium.

Oxidative stress is a phenomenon caused by an imbalance between production and accumulation of oxygen reactive species (ROS) in cells and tissues and the ability of a biological system to detoxify these reactive products.

ROS can play, and in fact they do it, several physiological roles (i.e., cell signaling), and they are normally generated as by-products of oxygen metabolism; despite this Cited by: Mutations in SOD lead to diseases commonly associated with high oxidative stress such as familial amyotrophic lateral sclerosis, Parkinson’s Disease, and cardiovascular disease (Fukai et al., ; Noor et al., ; Tórsdóttir et al., ).

Overexpression of SOD inhibits LDL oxidation by endothelial cells (Fang et al., ).Cited by: 7. Oxidative stress also plays an important role in the disease, and a growing amount of data suggest a link between arterial dysfunction and oxidative stress. In this review, we present the current evidence for the involvement of endothelial dysfunction, arterial stiffness, and inflammation in.

Dear Colleagues, Cardiovascular disease is the leading cause of mortality and the most expensive health condition in the United States. Animal and human data implicate increased levels of reactive oxygen species (ROS) associated with oxidative stress in the pathogenesis of cardiovascular disease.

Age is an independent risk factor of cardiovascular disease, even in the absence of other traditional factors. Emerging evidence in experimental animal and human models has emphasized a central role for two main mechanisms of age-related cardiovascular disease: oxidative stress and inflammation.

Excess reactive oxygen species (ROS) and superoxide generated by oxidative stress and low-grade Cited by:   INTRODUCTION. Oxidative stress has been attributed to increases in morbidity and mortality in cardiac surgical patients, the critically ill and patients requiring haemodialysis (HD) [].These patients are exposed to various extracorporeal circulatory devices such as cardiopulmonary bypass (CPB), HD and extracorporeal membrane oxygenation (ECMO).Cited by: Inflammation triggered by oxidative stress is the cause of much, perhaps even most, chronic human disease including human aging.

The oxidative stress originates mainly in mitochondria from reactive oxygen and reactive nitrogen species (ROS/RNS) and can be identified in most of the key steps in the pathophysiology of atherosclerosis and the consequential clinical manifestations of Cited by: The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging.

Proposed scheme for the role of oxidative stress in the development of heart failure. Acknowledgements Dr. Singal is supported by a career award from the Medical Research Council of Canada, Ms. Khaper is supported by a fellowship from the Heart and Stroke Foundation of Canada and Dr.

Palace was supported by the Manitoba Health Research by: Oxidative stress and vascular endothelial dysfunction are established characteristics of cystic fibrosis (CF). Oxidative stress may contribute to vascular dysfunction via inhibition of nitric oxide (NO) bioavailability. Purpose. To determine if ingestion of a single antioxidant cocktail (AOC) improves vascular endothelial function in patients with CF.

by: 2. There is growing evidence that oxidative stress (defined as an imbalance between endogenous oxidants and antioxidants in favour of the former) contributes to mechanisms of vascular dysfunction.

7 These observations fit well with the recognition that increased oxidative stress may be central to the atherogenic process. 8 In this review, we will Cited by:   LDL are prominent targets for postprandial oxidative modification. Oxidative stress has been implicated in the pathogenesis of cardiovascular diseases or diabetic complications (21,22).Importantly, there is a link to central obesity ().However, the detailed relations among hyperlipidemia, hyperglycemia, hyperinsulinemia, and oxidative stress are still under by:.

Not only old people, but even the younger generation gets afflicted now. This chapter will focus on the role of oxidative stress, mitochondrial dysfunction, and autophagy on the pathogenesis of the various forms of cardiovascular diseases including heart failure, atherosclerosis, hypertension, myocardial infarction, and ischemia-reperfusion : Sharmistha Chatterjee, Uday Hossain, Parames C.

Sil.Endothelial dysfunction is one of the initial steps in the pathogenesis of atherosclerosis and development of cardiovascular disease in patients with diabetes mellitus. Several risk factors are associated with endothelial dysfunction and atherosclerosis, such as hypertension, dyslipidaemia, inflammation, oxidative stress, and advanced glycation-end products.

Among these risk factors, oxidative Cited by: Obstructive sleep apnea (OSA) is a frequent disease mainly affecting obese people and caused by repetitive collapse of the upper airways during sleep. The increased morbidity and mortality of OSA are mainly thought to be the consequence of its adverse effects on cardiovascular (CV) health.

In this context, oxidative stress induced by nocturnal intermittent hypoxia has been identified to play a Cited by: